Applying for postdocs: does size matter?

And of course it does! Not because I am a guy (haha), but the size of a lab is one of the major factors determining the atmosphere of lab. While bigger (and usually more famous) labs usually indicate good funding in general, it does not guarantee that you are swimming in money and have unlimited resources. In a lab that has 20+ postdocs, very often one project is done by more than three or four people. Hence the resources are divided and you may have to fight for it. Even worse, when it comes to publications, you may have to share co-authorship among two or even three people, and there may be a bitter fight of who comes first in the list. In a way, you are not only competing against other labs who are working on your subject, but also the people in your own environment! Also, your supervisor will not have time at all for guidance, you are pretty much on your own. Imagine the lab meeting schedule in a 20+ postdoc lab! You won't have one for every six months probably!

It basically all boils down to what type of person you are in a working environment. If you are a natural "fighter", then a bigger lab will be good for you. If not, and you need more help from your supervisor, perhaps a smaller lab with 3 or 4 postdocs (plus some students) will suit you the most.